Where are stem
cells used?

EBMT guidelines

Medicine is now moving forward and the list of diseases in which stem cell transplantation is a therapeutic standard is becoming longer and longer. See what diseases may be treated using stem cells (according to the guidelines of the European organization dealing with stem cell transplantation - EBMT (European Society for Blood and Marrow Transplantation)).

List of medical conditions treated with stem cells

Acute leukaemias

  • acute lymphoblastic leukaemia (ALL)
  • acute myeloid leukaemia (AML)
  • acute biphenotipic leukaemia
  • poorly differentiated acute leukaemia

Chronic leukaemias

  • chronic myeloid leukaemia (CML)
  • chronic lymphocytic leukaemia (CLL)
  • juvenile chronic myeloid leukaemia (JCML)
  • juvenile myelomonocytic leukaemia (Naegeleg leukaemia) (JMML)

Myelodisplastic syndrome

  • refractory anaemia (RA)
  • refractory anaemia with ringed sideroblasts (RARS)
  • refractory anaemia with excess blasts (RAEB)
  • refractory anaemia with excess blasts in transformation (RAEB-T)
  • chronic myelomonocytic leukaemia (CMML)

Diseases caused by stem cell defect

  • aplastic anaemia(severe)
  • Fanconi anaemia
  • paroxysmal nocturnal haemoglobinuria

Myeloproliferative syndromes

  • acute myelofibrosis
  • myelofibrosis
  • polycythaemia vera
  • Essential thrombocythemia

Hyperplastic disorders of lymphatic system

  • non-Hodgkin lymphoma
  • acute lymphogranuloma
  • prolimphocytic leukaemia

Phagocytic disorders

  • Chediak-Higashi syndrome
  • chronic granulomatous disease (CGD)
  • neutrophil actin dysfunction
  • reticular dysgenesis

Disorders caused by the absence or malfunctioning of enzymes

  • mucopolysaccharidoses  (MPS)
  • Scheie syndrome (MPS-IS)
  • Hunter syndrome(MPS-II)
  • Sanfilippo syndrome (MPS-III)
  • Morquio syndrome (MPS-IV)
  • Maroteaux-Lamy syndrome (MPS-VI)
  • Sly syndrome, beta- glucoronidase deficiency (MPS-VII)
  • adrenoleukodystrophy
  • mucolipidosis II
  • Krabbe disease
  • Gaucher disease
  • Niemann-Pick disease
  • Wolman disease
  • metachromatic leukodystrophy

Histiocytic disorders

  • familial erythrophagocytic  lymphohistiocytosis
  • histiocytosis -X
  • hemophagocytosis

Inherited red blood cell abnormalities

  • beta thalassemia
  • pure red cell aplasia
  • sickle cell anaemia

Inherited immune system disorders

  • telangiectasia
  • Kostmann syndrome
  • leukocyte adhesion deficiency
  • DiGeorge syndrome
  • bare lymphocyte syndrome
  • Omenn syndrome
  • severe combined immunodeficiency (SCID)
  • SCID adenosine deaminase deficiency
  • SCID T and B lymphocytes negative
  • SCID T lymphocytes negative and B lymphocytes positive
  • common variable immunodeficiency
  • Wiskotta Aldrich syndrome
  • X-linked lymphoproliferative disorder

Other inherited conditions

  • Lesch-Nyhan syndrome
  • cartilage-hair hypoplasia
  • Glanzmann’s thrombasthenia
  • osteopetrosis (marble bone disease)

Hereditary thrombotic disorders

  • mega-karyocytosis (inherited thrombocythemia)

Plasma cell disorders

  • multiple myeloma
  • plasmocythic leukaemia
  • Waldenström’s macroglobulinemia

Other forms of cancer

  • breast cancer
  • Ewing’s sarcoma
  • neuroblastoma (sympathicoblastoma)
  • kidney cancer

Administration of stem cells brings benefits to patients with neurological disorders such as: autism and cerebral palsy

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